Search
telmisartan (Micardis)
Tradename: Micardis.
Indications:
- treatment of hypertension*
- chronic heart failure
- left ventricular systolic dysfunction
- diabetic nephropathy
- nondiabetic proteinuric nephropathy
- myocardial infarction [3]
- ischemic stroke [3]
;
* Telmisartan superior in controlling 24-hour blood pressure compared with other ARBs [4]
* Telmisartan with similar cardiovascular outcomes to those of other ARBs [4]
Dosage: 20-80 mg PO QD
Tabs: 20, 40, 80 mg
Pharmacokinetics:
1) bioavailablity 42-58%, orally active (not prodrug)
2) peak effect 0.5-1 hour
3) metabolized via conjugation to inactive metabolites
4) terminal 1/2life of 24 hours
5) 97% excreted in feces
6) clearance: 800 mL/min
Adverse effects:
- see ARB
Drug interactions:
1) weak inhibitor of cyt P450 2C19
2) telmisartain may increase levels of:
- digoxin, Li+,
3) K+ & K+-sparing diuretics may increase risk of hyperkalemia
4) warfarin ?
Mechanism of action:
- angiotensin II receptor antagonist
- angiotensin II receptor type 2 & 4-stimulating antihypertensive
see ACE inhibitors vs angiotensin receptor blockers (ARB)
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with ARBs
General
angiotensin II receptor antagonist (ARB)
Properties
Database Correlations
PUBCHEM correlations
References
- Kaiser Permanente Northern California Regional
Drug Formulary, Update 9/99
- Journal Watch 24(23):174, 2004
Barnett AH, Bain SC, Bouter P, Karlberg B, Madsbad S, Jervell J,
Mustonen J; Diabetics Exposed to Telmisartan and Enalapril Study Group.
Angiotensin-receptor blockade versus converting-enzyme inhibition
in type 2 diabetes and nephropathy.
N Engl J Med. 2004 Nov 4;351(19):1952-61. Epub 2004 Oct 31.
PMID: 15516696
- Deprecated Reference
- Yum Y, Kim JH, Joo HJ, Kim YH, Kim EJ
Three-Year Cardiovascular Outcomes of Telmisartan in Patients with Hypertension:
An Electronic Health Record - Based Cohort Study.
Am J Hypertens. 2024 Jan 29:hpae012.
PMID: 38285627
https://academic.oup.com/ajh/advance-article-abstract/doi/10.1093/ajh/hpae012/7591421
Component-of
amlodipine/indapamide/telmisartan
amlodipine/telmisartan (Twynsta)
hydrochlorothiazide/telmisartan