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teixobactin
Newly discovered. experimental drug.
Epidemiology:
- extracted from bacteria living in dirt
Antimicrobial activity:
Gram positive bacteria, including
- methicillin-resistant Staphylococcus aureus (MRSA)
Mechanism of action:
- binds to lipid II, precursor of peptidoglycan
- unlike vancomysin, binds modified forms of lipid II
Comparative biology:
- effective in mice
Notes:
- properties of teixobactin may suggest path towards developing antibiotics likley to avoid development of resistance [1]
General
antibacterial glycopeptide
References
- Ling L. Schneider T, Peoples AJ et al
A new antibiotic kills pathogens without detectable resistance.
Nature. Jan 7, 2015
PMID: 25561178
http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature14098.pdf