teicoplanin

Dosage: - 6 mg/kg/day Dosage adjustment in renal failure: creatinine clearance dosage > 50-90 mL/min 24 hour dosing 10-50 mL/min* 48 hour dosing < 10 mL/min# 72 hour dosing * same dose for continuous arteriovenous hemofiltration # same dose for hemodialysis Pharmacokinetics: - 1/2life 45 hours (62-230 hours ESRD) Antimicrobial activity: Gram positive - Streptococcus - Streptococcus group A - Streptococcus group B - Streptococcus group C - Streptococcus group G - Streptococcus pneumonia - Enterococcus faecalis - Enterococcus faecium (+/-) - Staphylococcus aureus (MSSA) - Staphylococcus aureus (MRSA) - Staphylococcus epidermidis (+/-) Anaerobes - Clostridium difficile (+/-) - Clostridium species Drug interactions: - teicoplanin & aminoglycosides are incompatible in solution Laboratory: 1) specimen: a) serum urine b) stable for 1 year at -20 degrees C 2) methods: a) serum: bioassay, SPERA, RASA, FPIA, HPLC b) urine: bioassay, SPERA, HPLC 3) interferences: -> lysed erythrocytes & presence of other antibiotics interfere with bioassay Mechanism of action: -> mixture of 6 glycopeptides

Properties

MOTIF: glycosylation site MISC-INFO: 1/2life 32-130 HOURS therapeutic-range 5-10 MG/ML protein-binding 88-91% elimination by hemodialysis -