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thyrotroph embryonic factor (TEF)
Function:
1) transcription factor
2) binds to & transactivates the TSHB promoter
3) binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'
4) binds DNA as a homodimer or a heterodimer
5) can form a heterodimer with DBP
6) accumulates according to a robust circadian rhythm
Structure:
1) belongs to the bZIP family, PAR subfamily
2) contains 1 bZIP domain
Compartment: nucleus
General
other protein
Properties
SIZE: MW = 33 kD
entity length = 303 aa
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 166-217
MOTIF: proline residue (SEVERAL)
DNA-binding motif
SITE: 239-257
leucine zipper
SITE: 268-282
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 188595
UniProt Q10587
Pfam PF07716
References
UniProt :accession Q10587