Search
transcriptional enhancer factor TEF-3; TEA domain family member 4; TEAD-4; transcription factor 13-like 1; transcription factor RTEF-1 (TEAD4, RTEF1, TCF13L1, TEF3)
Function:
- transcription factor
- role in the Hippo signaling pathway, a pathway involved in organ size control & tumor suppression
- mediates expression of YAP1 & WWTR1/TAZ, thus regulating cell proliferation, migration & epithelial mesenchymal transition (EMT) induction
- binds specifically & non-cooperatively to the sph & GT-IIC 'enhansons' (5'-GTGGAATGT-3') & activates transcription
- binds to the M-CAT motif interacts with YAP1 & WWTR1/TAZ
Structure: contains 1 TEA DNA-binding domain
Compartment: nucleus
Expression:
- preferentially expressed in skeletal muscle
- lower expression in pancreas, placenta, & heart
General
TEA domain family protein
Properties
SIZE: entity length = 434 aa
MW = 48 kD
COMPARTMENT: cell nucleus
MOTIF: TEA domain
SITE: 38-105
Database Correlations
OMIM 601714
UniProt Q15561
Pfam PF01285
Entrez Gene 7004
Kegg hsa:7004
References
UniProt :accession Q15561