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transcriptional enhancer factor TEF-5; DTEF-1; TEA domain family member 3; TEAD-3 (TEAD3, TEAD5, TEF5)
Function:
- transcription factor
- role in the Hippo signaling pathway, a pathway involved in organ size control & tumor suppression
- mediates expression of YAP1 & WWTR1/TAZ, thus regulating cell proliferation, migration & epithelial mesenchymal transition (EMT) induction.
- binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
- interacts with YAP1 & WWTR1/TAZ
Structure:
- contains 1 TEA DNA-binding domain
Compartment: nucleus
Expression:
- preferentially expressed in the placenta
General
TEA domain family protein
Properties
SIZE: entity length = 435 aa
MW = 49 kD
COMPARTMENT: cell nucleus
MOTIF: TEA domain
SITE: 30-97
proline-rich region
SITE: 146-213
MOTIF: proline residue (SEVERAL)
transcriptional activation domain
SITE: 173-435
Database Correlations
OMIM 603170
UniProt Q99594
Pfam PF01285
Entrez Gene 7005
Kegg hsa:7005
References
UniProt :accession Q99594