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transcriptional enhancer factor TEF-4; TEA domain family member 2; TEAD-2 (TEAD2, TEF4)
Function:
- transcription factor
- role in the Hippo signaling pathway, a pathway involved in organ size control & tumor suppression
- mediates expression of YAP1 & WWTR1/TAZ, thus regulating cell proliferation, migration & epithelial mesenchymal transition (EMT) induction
- binds to the SPH & GT-IIC 'enhansons' (5'-GTGGAATGT-3')
- may be involved in regulation of neural development
- binds to the M-CAT motif
- interacts with YAP1 & WWTR1/TAZ
Structure:
- contains 1 TEA DNA-binding domain
Compartment: nucleus
General
TEA domain family protein
Properties
SIZE: entity length = 447 aa
MW = 49 kD
COMPARTMENT: cell nucleus
MOTIF: TEA domain
SITE: 40-107
proline-rich region
SITE: 152-216
MOTIF: proline residue (SEVERAL)
transcriptional activation domain
SITE: 172-447
Database Correlations
OMIM 601729
UniProt Q15562
Pfam PF01285
Entrez Gene 8463
Kegg hsa:8463
References
UniProt :accession Q15562