tudor domain-containing protein 7; PCTAIRE2-binding protein; tudor repeat associator with PCTAIRE 2; trap (TDRD7, PCTAIRE2BP)

Function: - component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes - probably acts by binding to specific mRNAs & regulating their translation. - required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 & HSPB1 in the developing lens - also required during spermatogenesis - found in a mRNP complex, composed of at least TDRD1, TDRD6, TDRD7 & DDX4 - found in a complex containing CABLES1, CDK16 & CDK17 - interacts with CABLES1, CDK17 & PIWIL1 Structure: - belongs to the TDRD7 family - contains 3 HTH OST-type domains - contains 2 Tudor domains Compartment: - cytoplasm - localizes to cytoplasmic RNA granules - present in chromatoid body of spermatids - detected in the intermitochondrial cementin in pachytene spermatocytes Alternative splicing: named isoforms=3 Pathology: - defects in TDRD7 are the cause of cataract congenital autosomal recessive type 4

General

phosphoprotein tudor domain-containing protein

Properties

SIZE: entity length = 1098 aa MW = 124 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: HTH OST-type 1 {3-76} HTH OST-type 2 {233-302} Ser phosphorylation site {S319} HTH OST-type 3 {337-406} Tudor domain SITE: 513-570 Tudor domain SITE: 703-760 CDK17 interaction {861-1098} MOTIF: Ser phosphorylation site {S862} binding site SITE: 893-1098 FOR-BINDING-OF: CDK5 & ABL1 enzyme substrate 1

Database Correlations

OMIM correlations UniProt Q8NHU6 PFAM correlations Entrez Gene 23424 Kegg hsa:23424

References

UniProt :accession Q8NHU6