tudor domain-containing protein 3 (TDRD3)

Function: - scaffolding protein - specifically recognizes & binds dimethylarginine-containing proteins - in nucleus, acts as a coactivator: recognizes & binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a & H4R3me2a) & recruits proteins at these arginine-methylated loci - in cytoplasm, may play a role in the assembly &/or disassembly of mRNA stress granules & in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins - component of mRNA stress granules - interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 & DDX3X or DDX3Y & with the small nuclear ribonucleoprotein- associated proteins SNRPB & SNRPN - interacts with Lys-48-linked tetra-ubiquitin - does not interact with monoubiquitin or Lys-63-linked ubiquitin chains Structure: - the Tudor domain specifically recognizes & binds asymmetric dimethylation of histone H3 Arg-17 (H3R17me2a) & histones H4 Arg-3, 2 tags for epigenetic transcriptional activation - contains 1 Tudor domain - contains 1 UBA domain Compartment: - cytoplasm, nucleus - predominantly cytoplasmic - associated with actively translating polyribosomes & with mRNA stress granules Alternative splicing: named isoforms=3 Expression: - detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

General

phosphoprotein tudor domain-containing protein

Properties

SIZE: entity length = 651 aa MW = 73 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: UBA domain {193-233} Ser phosphorylation site {S256} Tudor domain SITE: 555-615

Database Correlations

OMIM 614392 UniProt Q9H7E2 PFAM correlations Entrez Gene 81550 Kegg hsa:81550

References

UniProt :accession Q9H7E2