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teratocarcinoma-derived growth factor 1; cripto-1 growth factor; CRGF; EGF-like cripto protein CR1 (TDGF1, CRIPTO)
Function:
- could play a role in the determination of epiblastic cells that subsequently give rise to the mesoderm
- interacts with the activin type-1 receptor ACVR1B
Structure: contains 1 EGF-like domain
Compartment: cell membrane; lipid-anchor, GPI-anchor
Expression:
- preferentially expressed in gastric carcinomas & colorectal carcinomas than in their normal counterparts
- expressed in breast & lung
General
glypiated protein
Properties
SIZE: entity length = 188 aa
MW = 21 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-30}
EGF domain {78-107}
MOTIF: N-glycosylation site {N79}
cysteine residue {C82}
MODIFICATION: cysteine residue {C89}
cysteine residue {C83}
MODIFICATION: cysteine residue {C95}
cysteine residue {C89}
MODIFICATION: cysteine residue {C82}
cysteine residue {C95}
MODIFICATION: cysteine residue {C83}
cysteine residue {C97}
MODIFICATION: cysteine residue {C106}
cysteine residue {C106}
MODIFICATION: cysteine residue {C97}
cysteine residue {C115}
MODIFICATION: cysteine residue {C133}
cysteine residue {C128}
MODIFICATION: cysteine residue {C149}
cysteine residue {C131}
MODIFICATION: cysteine residue {C140}
cysteine residue {C133}
MODIFICATION: cysteine residue {C115}
cysteine residue {C140}
MODIFICATION: cysteine residue {C131}
cysteine residue {C149}
MODIFICATION: cysteine residue {C128}
glycosyl phosphatidylinositol [GPI] membrane anchor {N150}
Database Correlations
OMIM 187395
UniProt P13385
Pfam PF09443
Entrez Gene 6997
Kegg hsa:6997
References
UniProt :accession P13385