T cell receptor delta (TCRD, TRD)

Function: - the T-cell receptor forms non covalent interactions with a series of transmembrane signalling subunits, delta, gamma, epsilon & zeta each of which contains 1-3 copies of the motif YXX[LI]X(6-8)YXX[LI] - phosphorylation of these Tyr-containing sites in antigen- stimulated T-cells (presumably by lck) creates a binding site(s) for the SH2-domains of Zap-70. - Zap-70, in turn stimulates PLC-gamma1, leading to the rise in intracellular Ca⁺²

Related

lck proto-oncogene protein phospholipase C-gamma 1 (PLCG1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, PLC-2) TCR gamma delta Ag in tissue TCR gamma delta cells in blood Zap-70 tyrosine kinase; zeta-associated protein 70 kD; Syk-related tyrosine kinase (ZAP70, SRK)

Properties

COMPARTMENT: plasma membrane MOTIF: transmembrane domain Tyr phosphorylation site

References

- Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: 7531822