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T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein, TCL1 oncogene protein, TCL1A, TCL1)
Structure: homodimer
Compartment: microsome
Expression:
- restricted in the T-cell lineage to immature thymocytes & activated peripheral lymphocytes
- preferentially expressed early in T-lymphocyte & B-lymphocyte differentiation
Pathology:
- chromosomal aberrations involving T-cell receptor alpha/delta loci activating TCL1A are found in chronic T-cell leukemias
- translocation t(14;14)(q11;q32)
- translocation t(7;14)(q35;q32)
- inversion inv(14)(q11;q32)
Related
TCL-1A Ag in tissue
General
proto oncogene protein
Properties
SIZE: MW = 13 kD
entity length = 114 aa
Database Correlations
OMIM 186960
UniProt P56279
Pfam PF01840
References
- UniProt :accession P56279
- Atlas Genet. Cytogenet. Oncol. Haematol.
http://atlasgeneticsoncology.org/Genes/TCL1ID66.html