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transcription factor 12; helix loop helix transcription factor-4; transcription factor HTF-4; E-box-binding protein; DNA-binding protein HTF4 (TCF12; HEB; HTF4)
Function:
- binds specifically to oligomers of E-box motifs
- may play important roles during development of the nervous system as well as in other organ systems
- efficient DNA binding requires dimerization with another bHLH protein
- forms homo- or heterooligomers with myogenin, E12 & ITF2 proteins
- interacts with PTF1A (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression:
- expressed in several tissues & cell types including skeletal muscle, thymus, & a B-cell line
General
basic helix loop helix (bHLH) family transcription factor
phosphoprotein
Properties
SIZE: entity length = 682 aa
MW = 73 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S44}
Ser phosphorylation site {S47}
leucine zipper
SITE: 119-140
FOR-BINDING-VIA: leucine zipper
Ser phosphorylation site {S333}
DNA-binding motif
SITE: 577-589
helix-loop-helix
NAME: helix-loop-helix
SITE: 590-631
FOR-BINDING-VIA: helix-loop-helix
Class A specific {632-655}
Database Correlations
OMIM 600480
UniProt Q99081
Pfam PF00010
Kegg hsa:6938
References
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/TCF12ID406.html
- OMIM :accession 600480
- UniProt :accession Q99081
Component-of
pancreas transcription factor 1 complex (PTF1)