Search
elongin B; elongin 18 kD subunit; transcription elongation factor B polypeptide 2; RNA polymerase II transcription factor SIII subunit B; SIII p18TCEB2 (EloB, TCEB2)
Function:
- regulatory component of elongin
- component of elongin BC complex
- part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 & a substrate adapter protein that can be either SOCS1, TCEB3, VHL or WSB1 (putative)
- substrate adapter protein can be a viral protein such as HIV Vif
- interacts with VHL protein modification; protein ubiquitination
Structure: contains 1 ubiquitin-like domain
Compartment: nucleus (probable)
General
protein subunit
Properties
SIZE: entity length = 118 aa
MW = 13 kD
COMPARTMENT: cell nucleus
MOTIF: Ubiquitin-like {1-66}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
References
- OMIM :accession 600787
- UniProt :accession Q15370
Component-of
ECS(WSB1) complex
Databases & Figures
OMIM 600787
UniProt Q15370
Entrez Gene 6923
Kegg hsa:6923
HIF-1 pathway