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transcription elongation factor A protein 1; transcription elongation factor S-II protein 1; transcription elongation factor TFIIS.o (TCEA1 GTF2S TFIIS)
Function:
- necessary for efficient RNA polymerase 2 transcription elongation past template-encoded arresting sites
- the arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes
- cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
- S-II binds to RNA-polymerase II in the absence of transcription
- interacts with EAF2 (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the TFS-II family
- contains 1 TFIIS central domain
- contains 1 TFIIS N-terminal domain
- contains 1 TFIIS-type Zn+2 finger
Compartment: nucleus
Alternative splicing:
- named isoforms=2
- additional isoforms seem to exist
Pathology:
- chromosomal translocation t(3;8)(p21;q12) involving TCEA1 with PLAG1 may be a cause of salivary gland pleiomorphic adenomas
General
DNA-binding protein
phosphoprotein
transcription elongation factor
zinc finger protein
Properties
SIZE: entity length = 301 aa
MW = 34 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
TFIIS N-terminal {3-80}
Ser phosphorylation site {S81}
Ser phosphorylation site {S97}
Ser phosphorylation site {S100}
Thr phosphorylation site {T108}
Ser phosphorylation site {S110}
Tyr phosphorylation site {Y126}
TFIIS central {140-256}
Zinc finger
NAME: Zinc finger
SITE: 259-299
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601425
UniProt P23193
PFAM correlations
Kegg hsa:6917
References
UniProt :accession P23193