Rho-related GTP-binding protein RhoQ; Ras-related GTP-binding protein TC10; Ras-like protein family member 7A (RHOQ, ARHQ, RASL7A, TC10)

Function: - plasma membrane-associated small GTPase which cycles between an active GTP-bound & an inactive GDP-bound state - in active state, binds to a variety of effector proteins to regulate cellular responses - involved in epithelial cell polarization processes - may play a role in CFTR trafficking to the plasma membrane - causes the formation of thin, actin-rich surface projections called filopodia - regulated by guanine nucleotide exchange factors which promote exchange of bound GDP for free GTP, GTPase activating proteins which increase the GTP hydrolysis activity, & GDP dissociation inhibitors which inhibit dissociation of the nucleotide from the GTPase - interacts with CDC42EP4 in a GTP-dependent manner - interacts with TCGAP/SNX26 (putative) - interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G & probably PARD6B (GTP-dependent) - component of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) & some atypical PKC protein (PRKCI or PRKCZ) - interacts with EXO70 (GTP-dependent) - interacts with GOPC Structure: - may be post-translationally modified by both palmitoylation & polyisoprenylation - belongs to the small GTPase superfamily, Rho family Compartment: cytoplasm. cell membrane; lipid-anchor

Properties

SIZE: entity length = 205 aa MW = 23 kD COMPARTMENT: cytoplasm MOTIF: GTP-binding site SITE: 16-23 Effector region {38-46} GTP-binding site SITE: 63-67 GTP-binding site SITE: 121-124 CaaX motif SITE: C-TERMINUS QUALITIES: AAX-TRUNCATED CARBOXYMETHYLATED EFFECTOR-BOUND: farnesyl BOUND-VIA: cysteine residue

Database Correlations

OMIM 605857 UniProt P17081 Pfam PF00071 Entrez Gene 23433 Kegg hsa:23433

References

UniProt :accession P17081