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TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; transcription initiation factor TFIID TBP subunit; p38TFIID; p38tau (TBP, GTF2D1, TF2D, TFIID)

Function: - subunit of TFIID which binds to TATA box - binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex, playing a role in activation of eukaryotic genes transcribed by RNA polymerase 2 - binds DNA as monomer - interacts with TAFs, TFIIB, NCOA6, DRAP1, DR1 & ELF3 - interacts with SPIB, SNAPC1, SNAPC2 & SNAPC4 - interacts with HIV-1 Tat - interacts with UTF1 which acts as a coactivator of ATF2 transcriptional activity - interacts with GPBP1 (putative) - interacts with BRF2 Structure: belongs to the TBP family Compartment: nucleus Pathology: - CAG trinucleotide repeat expansion in gene for p38TFIID associated with spinocerebellar ataxia 17 Polymorphism: - the poly-Gln (CAG) region of TBP is highly polymorphic (25-42 repeats) in normal individuals & is expanded to about 47- 63 repeats in spinocerebellar ataxia 17 (SCA17) patients Laboratory: - TBP gene CAG repeats

Interactions

molecular events

General

DNA-binding protein transcription factor IID subunit

Properties

SIZE: entity length = 339 aa MW = 38 kD COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {55-95} MOTIF: glutamine residue (SEVERAL) consensus repeat {165-241} consensus repeat {255-332}

Database Correlations

OMIM correlations UniProt P20226 Pfam PF00352 Entrez Gene 6908 Kegg hsa:6908

References

  1. Ross CA, McInnis MG, Margolis RL, Li SH. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: 7689767
  2. Uniprot :accession P20226
  3. OMIM :accession 600075
  4. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/TBP

Component-of

molecular complex