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TBC1 domain family member 3; prostate cancer gene 17 protein; protein TRE17-alpha; Rab GTPase-activating protein PRC17 (TBC1D3, PRC17, TBC1D3A)
Function:
- acts as a GTPase activating protein for RAB5
- does not act on RAB4 or RAB11
Structure: contains 1 Rab-GAP TBC domain
Expression:
- expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine & peripheral blood leukocytes
Pathology:
- overexpressed in prostate cancers
General
TBC1 domain family member
Properties
SIZE: entity length = 549 aa
MW = 62 kD
MOTIF: rab-GAP domain
NAME: rab-GAP domain
SITE: 101-293
phosphorylation site
Database Correlations
OMIM 607741
UniProt Q8IZP1
Pfam PF00566
LOCUS-LINK correlations
KEGG correlations
References
UniProt :accession Q8IZP1