Search
Tax1-binding protein 1 (TRAF6-binding protein, TAX1BP1, T6BP, PRO0105)
Function:
1) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity
2) degraded by caspase-3-like family proteins upon TNF-induced apoptosis
3) role in pro-inflammatory cytokine IL-1 signaling
4) interacts with TRAF6 (IL-1-dependent)
5) interacts with TNFAIP3 & STARD13
Structure: homooligomer
Alternative splicing: named isoforms=3
Expression: expressed in all tissues tested
General
other protein
Properties
SIZE: MW = 91 kD
entity length = 789 aa
MOTIF: coiled coil {144-599}
MOTIF: Oligomerization {320-420}
Database Correlations
OMIM 605326
UniProt Q86VP1
Pfam PF07888
References
UniProt :accession Q86VP1