Tax1-binding protein 3 (Tax interaction protein 1, TIP-1, glutaminase-interacting protein 3, TAX1BP3, TIP1)

Function: - may regulate a number of protein-protein interactions by competing for PDZ domain binding sites - interacts via its PDZ domain with GLS2 (via PDZ domain) - binds CTNNB1 (via PDZ domain) inhibiting - transcriptional activity of CTNNB1 - Wnt signaling pathway (putative) - interacts (via PDZ domain) with ARHGEF16 - competes with LIN7A for KCNJ4 binding (via PDZ domain), & this promotes KCNJ4 internalization - interaction with & RTKN (via C-terminal region) facilitates Rho-mediated activation of the FOS serum response element (SRE) (putative) - role in activation of CDC42 by the viral protein HPV16 E6 - interacts with HTLV-1 TAX protein Structure: - contains 1 PDZ domain (DHR domain) Compartment: - cytoplasm, nucleus - cell membrane, cytoplasmic side - recruited to cell membrane by interaction with membrane proteins Expression: - ubiquitous - detected in brain, heart, kidney, lung, small intestine & skeletal muscle - expressed in HeLa cells & weakly in peripheral blood leukocytes

Properties

SIZE: MW = 14 kD entity length = 124 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl PDZ domain NAME: PDZ domain SITE: 15-112 MOTIF: Ser phosphorylation site {S61}

Database Correlations

UniProt O14907 Pfam PF00595 Entrez Gene 30851 Kegg hsa:30851

References

UniProt :accession O14907