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contactin 2; axonin-1; transient axonal glycoprotein-1; TAG-1 (CNTN2)

Function: 1) initial growth & guidance of axons 2) cell adhesion (putative) Structure: - belongs to the immunoglobulin superfamily, contactin family - contains 4 fibronectin F3 modules - contains 6 Ig-like C2-type domain (immunoglobulin-like) Compartment: - cell membrane, lipid-anchor, GPI-anchor - attached to neuronal membrane by GPI-anchor & also released from neurons Expression: - transiently expressed presumably prior to myelination

General

contactin

Properties

SIZE: MW = 113 kD entity length = 1040 aa COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: epithelial cell MOTIF: signal sequence {1-30} immunoglobulin superfamily domain {43-128} MOTIF: cysteine residue {C61} MODIFICATION: cysteine residue {C111} N-glycosylation site {N76} cysteine residue {C111} MODIFICATION: cysteine residue {C61} immunoglobulin superfamily domain {133-222} MOTIF: cysteine residue {C155} MODIFICATION: cysteine residue {C207} N-glycosylation site {N198} N-glycosylation site {N204} cysteine residue {C207} MODIFICATION: cysteine residue {C155} immunoglobulin superfamily domain {239-322} MOTIF: cysteine residue {C261} MODIFICATION: cysteine residue {C306} cysteine residue {C306} MODIFICATION: cysteine residue {C261} immunoglobulin superfamily domain {327-411} MOTIF: cysteine residue {C348} MODIFICATION: cysteine residue {C395} cysteine residue {C395} MODIFICATION: cysteine residue {C348} immunoglobulin superfamily domain {417-504} MOTIF: N-glycosylation site {N461} N-glycosylation site {N477} N-glycosylation site {N498} immunoglobulin superfamily domain {509-603} MOTIF: N-glycosylation site {N525} proline-rich region SITE: 606-612 MOTIF: proline residue (SEVERAL) fibronectin type III domain or F3 module {607-703} fibronectin type III domain or F3 module {710-807} fibronectin type III domain or F3 module {812-908} MOTIF: N-glycosylation site {N830} N-glycosylation site {N904} fibronectin type III domain or F3 module {912-1002} MOTIF: N-glycosylation site {N918} N-glycosylation site {N940} glycosyl phosphatidylinositol [GPI] membrane anchor {C-TERMINUS}

Database Correlations

OMIM 190197 UniProt Q02246 PFAM correlations Entrez Gene 6900 Kegg hsa:6900

References

  1. Schachner M, Martini R. Glycans and the modulation of neural-recognition molecule function. Trends Neurosci. 1995 Apr;18(4):183-91. Review. PMID: 7539963 (HNK-I)
  2. UniProt :accession Q02246