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Tau-tubulin kinase 2 (TTBK2, KIAA0847)
Function:
1) serine/threonine protein kinase
2) phosphorylates microtubule-assciated protein tau on Ser
Structure:
- belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family
- contains 1 protein kinase domain
Alternative splicing: named isoforms=3
Pathology:
- defects in TTBK2 are the cause of spinocerebellar ataxia type 11
Related
ubiquitin-like PHD & RING finger domain-containing protein (UHRF)
General
serine/threonine kinase
Properties
SIZE: entity length = 1244 aa
MW = 137 kD
STATE: active state
MOTIF: kinase domain
SITE: 21-284
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 27-35
ATP-binding site
NAME: ATP-binding site
SITE: 50-50
aspartate residue {D141}
threonine-rich region {307-314}
MOTIF: threonine residue (SEVERAL)
Ser phosphorylation site {S786}
serine-rich region {1150-1203}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 611695
UniProt Q6IQ55
Pfam PF00069
Entrez Gene 146057
Kegg hsa:146057
ENZYME 2.7.11.1
References
- UniProt :accession Q6IQ55
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/TTBK2