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Tau-tubulin kinase 1; brain-derived tau kinase (TTBK1, BDTK, KIAA1855)
Function:
- serine/threonine protein kinase
- phosphorylates TAU on Ser, Thr & Tyr
- induces aggregation of TAU
Cofactor: Mg+2 > Mn+2
Structure:
- belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family
- contains 1 protein kinase domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in neurons
- expressed in the brain, particularly in cerebral cortex & hippocampus
- weakly expressed in spinal cord
- weakly expressed in testis
- not expressed in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea
Note:
- uncertain whether Met-1 or Met-14 is the initiator
General
serine/threonine kinase
Properties
SIZE: entity length = 1321 aa
MW = 143 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 34-297
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 40-48
ATP-binding site
NAME: ATP-binding site
SITE: 63-63
aspartate residue {D154}
S/T phosphorylation site
coiled coil {685-781}
MOTIF: glutamate-rich region {733-771}
MOTIF: glutamate residue (SEVERAL)
alanine-rich region {772-777}
MOTIF: alanine residue (SEVERAL)
serine-rich region {1110-1114}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 1197-1289
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt Q5TCY1
Pfam PF00069
Entrez Gene 84630
Kegg hsa:84630
References
UniProt :accession Q5TCY1