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tau positron emission tomography (tau PET ([18F]RO948), tau PET)

Indications: - diagnosis of Alzheimer's disease Clinical significance: - useful when added to an already extensive diagnostic workup that included CSF biomarkers for Alzheimer's disease - most useful in patients positive for beta-amyloid [1] - tau PET predicts cognitive change better than amyloid PET & MRI [3] - tau PET may support prognosis in preclinical & prodromal stages of AD - tau PET outperforms amyloid PET or brain MRI in predicting conversion of mild cognitive impairment to dementia [2] - increased 18F flortaucipir (FTP) tau PET levels associated with declines in all cognitive domains - only quantitative temporal tau PET improves prediction of all-cause dementia in patients with mild cognitive impairment [2]

General

positron emission tomography (PET, PET scan)

References

  1. Smith R et al. Clinical utility of tau positron emission tomography in the diagnostic workup of patients with cognitive symptoms. JAMA Neurol 2023 Jul; 80:749; [e-pub] PMID: 37213093 PMCID: PMC10203972 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2805318
  2. Groot C, Smith R, Collij LE et al. Tau positron emission tomography for predicting dementia in individuals with mild cognitive impairment. JAMA Neurol 2024 Aug; 81:845-856 PMID: 38857029 PMCID: PMC11165418 Free PMC article https://jamanetwork.com/journals/jamaneurology/fullarticle/2819811
  3. Ossenkoppele R, Smith R, Mattsson-Carlgren N et al Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease. A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging. JAMA Neurol. Published online June 28, 2021. PMID: 34180956 https://jamanetwork.com/journals/jamaneurology/fullarticle/2781465