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Tau/Abeta42 in CSF; amyloid-tau neurodegeneration (ATN) profile

Indications: - in conjunction with phosphorylated tau in CSF (phospho-Thr(181) tau), may be useful for predicting likelihood of MCI progressing to Alzheimer's disease [1,2] Differential diagnosis: - Alzheimer's disease

Related

amyloid-beta peptide 42 in CSF cerebrospinal fluid microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau) microtubule-associated protein tau in serum/plasma

Specific

phosphorylated tau/Abeta42 in CSF

General

protein/peptide testing

References

  1. Mattsson N et al. CSF Biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA 2009 Jul 22/29; 302:385. PMID: 19622817 - Petersen RC and Trojanowski JQ. Use of Alzheimer disease biomarkers: Potentially yes for clinical trials but not yet for clinical practice. JAMA 2009 Jul 22/29; 302:436. PMID: 19622825
  2. Soldan A, Pettigrew C, Fagan AM et al. ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes. Neurology 2019 Apr 2; 92:e1567 PMID: 30842300 https://n.neurology.org/content/92/14/e1567
  3. Lab Tests Online http://www.labtestsonline.org/understanding/analytes/tau/faq.html - Tau/Abeta42 Lab Tests Online: tau

Components

amyloid-beta peptide 42 in CSF microtubule-associated protein tau in CSF