taste receptor, type 2, member 16 (T2R16, TAS2R16)

Function: 1) perception of bitterness 2) gustducin-linked 3) bitter taste receptor for phytonutrient beta glucopyranosides a) some of which are toxic b) some of which may lower risk of cancer &/or cardiovascular disease 4) stimulates alpha gustducin (putative) 5) PLC-beta-2 6) gating of TRPM5 Structure: belongs to the G-protein coupled receptor T2R family Compartment: membrane Expression: - expressed in subsets of taste receptor cells of the tongue & palate epithelium, exclusively in gustducin-positive cells Polymorphism: - Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [2]

Properties

SIZE: MW = 34 kD entity length = 291 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-1} transmembrane domain {2-22} cytoplasmic loop {23-41} transmembrane domain {42-62} exoplasmic loop {63-84} MOTIF: N-glycosylation site {N80} transmembrane domain {85-105} cytoplasmic loop {106-125} transmembrane domain {126-146} exoplasmic loop {147-182} MOTIF: N-glycosylation site {N163} transmembrane domain {183-203} cytoplasmic loop {204-228} transmembrane domain {229-249} exoplasmic loop {250-257} transmembrane domain {258-278} cytoplasmic domain {279-291}

Database Correlations

OMIM correlations UniProt Q9NYV7 Pfam PF05296 Entrez Gene 50833 Kegg hsa:5083