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targeted alpha therapy
Indications:
- radiation therapy for targeted treatment of cancer
- radium-223 is a commercially available targeted alpha therapy for treatment of metastatic castration-resistant prostate cancer with bone metastases
Mechanism of action:
- high-energy emission of short-range alpha particles causes double-stranded DNA breaks, eliciting cell death
- short-range emission of alpha particle radiation confines cytotoxic effect to targeted lesions & surrounding microenvironment
- no known resistance mechanism to alpha particles
General
radiation therapy (XRT)
References
- Targeted Alpha Therapy Working Group
Targeted Alpha Therapy, an Emerging Class of Cancer Agents. A Review.
JAMA Oncol. Published online September 20, 2018
PMID: 30326033
https://jamanetwork.com/journals/jamaoncology/fullarticle/2703121