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TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; I-TRAF (TANK, ITRAF)
Function:
- acts as a regulator of TRAF function by maintaining them in a latent state
- overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 & TNFR2
- blocks TRAF2 binding to LMP1 & inhibits LMP1-mediated NF-kappa-B activation
- may be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity
- phosphorylated by IKBKE
- interacts with TBK1 (via TRAF-C domain)
- interacts with TRAF1 (via TRAF-C domain)
- interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE
- interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 & TRAF3
- interacts with IKBKG; the interaction is enhanced by IKBKE & TBK1
- part of a ternary complex consisting of TANK, IKBKB & IKBKG
Structure: contains 1 C2H2-type Zn+2 finger
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression: ubiquitous
General
C2H2 type zinc finger protein
phosphoprotein
Properties
SIZE: entity length = 425 aa
MW = 48 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S116}
Ser phosphorylation site {S117}
Ser phosphorylation site {S126}
Ser phosphorylation site {S129}
TRAF family member interaction {172-191}
MOTIF: Thr phosphorylation site {T175}
Ser phosphorylation site {S208}
Thr phosphorylation site {T213}
Thr phosphorylation site {T224}
Ser phosphorylation site {S225}
Ser phosphorylation site {S228}
Ser phosphorylation site {S230}
Thr phosphorylation site {T244}
Ser phosphorylation site {S341}
Ser phosphorylation site {S354}
Ser phosphorylation site {S357}
Ser phosphorylation site {S380}
Zn finger C2H2-type
SITE: 394-420
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 603893
UniProt Q92844
Entrez Gene 10010
Kegg hsa:10010
References
UniProt :accession Q92844