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talazoparib (Talzenna)
Indications:
- treatment of childhood solid tumors
- androgen-independent metastatic prostate cancer
Dosage:
Tabs: 0.25 mg, 1 mg
Mechanism of action:
- inhibits poly(ADP-ribose) polymerase (PARP)
- prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway
- enhances the accumulation of DNA strand breaks, promotes genomic instability & eventually leads to apoptosis
- PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal & recruit other proteins to repair damaged DNA & is activated by single-strand DNA breaks
General
small inhibitory antineoplastic agent (ib drug)
PARP inhibitor
Database Correlations
PUBCHEM correlations
References
- PubChem: 71731823