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medication compliance (taking medicine)

Taking medication as prescribed. , Depression may compromise medication compliance. [1] Pharmacy-dispensed custom blister packs improves compliance [2] Adherence to antihypertensive drug treatment is poor [3] - 50% of patients self discontinue within 1 year - 10% of doses skipped on any given day - 95% of patients miss at least 1 dose/year - 50% miss at least 1 dose monthly - 50% take at least 1 drug holiday of at least 3 days yearly Patients are less likely to be compliant with their medications after CABG than after PCI [6] - direct observation benefits are not sustained past the period of direct observation [4] - outcome benefits of medication adherence may exceed benefits of the medications themselves (based on clinical trial data) confounding estimates of the true benefit of adherence [5] - text messaging may improve medication compliance [8] - electronic approaches improve medication adherence by ~10% [11] systems approach suggested [9] most commercially-available electronic adherence monitoring devices do capture whether patients adhere to drug regimens [10] patients who read visit notes have a better understanding of prescribed medications

Related

medication reconciliation

Specific

medication compliance in the elderly

General

pharmacology medical compliance; treatment compliance

References

  1. Gehi A et al, Depression and medication adherence in outpatients with coronary heart disease: Findings from the Heart and Soul Study. Arch Intern Med 2005; 165:2508 PMID: 16314548 - Katon W et al, Impact of antidepressant drug adherence on comorbid medication use and resource utilization. Arch Intern Med 2005; 165:2497 PMID: 16314547
  2. Lee JK et al, Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: A randomized controlled trial. JAMA 2006, 296 PMID: 17101639 - Simpson RJ JR Challenges for improving medication adherenece. JAMA 2006, 296 PMID: 17101641
  3. Vrijens B et al, Adherence to prescribed antihypertensive drug treatments: Longitudinal study of electronically compiled dosing histories. BMJ 2008, 336:1114 PMID: 18480115
  4. Berg KM et al. Lack of sustained improvement in adherence or viral load following a directly observed antiretroviral therapy intervention. Clin Infect Dis 2011 Nov 1; 53:936 PMID: 21890753
  5. LaFleur J, Nelson RE, Sauer BC, Nebeker JR. Overestimation of the effects of adherence on outcomes: a case study in healthy user bias and hypertension. Heart. 2011 Nov;97(22):1862-9. Epub 2011 May 17. PMID: 21586421
  6. Hlatky MA et al. Use of medications for secondary prevention after coronary bypass surgery compared with percutaneous coronary intervention. J Am Coll Cardiol 2013 Jan 22; 61:295. PMID: 23246391
  7. Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011 Feb;9(1):11-23. Review. PMID: 21459305
  8. Thakkar J et al. Mobile telephone text messaging for medication adherence in chronic disease: A meta-analysis. JAMA Intern Med 2016 Feb 1; PMID: 26831740 - Nieuwlaat R et al. Mobile text messaging and adherence of patients to medication prescriptions: A txt a dA keeps da doctR awA? JAMA Intern Med 2016 Feb 1 PMID: 26831149
  9. Lauffenburger JC, Choudhry NK. A Call for a Systems-Thinking Approach to Medication Adherence. Stop Blaming the Patient. JAMA Intern Med. Published online May 21, 2018 PMID: 29799994 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2681650
  10. Lou N. Rx Adherence Monitors Do Work... Mostly. Not all could record time of opening, however, in controlled lab experiments. MedPage Today. May 21, 2018 https://www.medpagetoday.com/primarycare/generalprimarycare/73004 - McGrady ME, et al An independent evaluation of the accuracy and usability of electronic adherence monitoring devices. Ann Intern Med 2018; PMID: 29800004
  11. Choudhry NK, Isaac T, Lauffenburger JC et al. Effect of a remotely delivered tailored multicomponent approach to enhance medication taking for patients with hyperlipidemia, hypertension, and diabetes: The STIC2IT cluster randomized clinical trial. JAMA Intern Med 2018 Aug 6; [e-pub]. PMID: 30083727
  12. DesRoches CM, Bell SK, Dong Z et al. Patients managing medications and reading their visit notes: A survey of OpenNotes participants. Ann Intern Med 2019 May 28; PMID: 31132794 https://annals.org/aim/article-abstract/2734788/patients-managing-medications-reading-visit-notes-survey-opennotes-participants?doi=10.7326%2fM18-3197 - Blumenthal D, Abrams MK. Ready or not, we live in an age of health information transparency. Ann Intern Med 2019 May 28; PMID: 31132792 https://annals.org/aim/article-abstract/2734888/ready-we-live-age-health-information-transparency?doi=10.7326%2fM19-1366
  13. Taking Medicine: NIH Senior Health http://nihseniorhealth.gov/takingmedicines/toc.html