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tafenoquine (Arakoda, Krintafel)
Indications:
- treatment of malaria
- Plasmodium vivax malaria
Contraindications:
- G6PD deficiency
Dosage:
- 200 mg QD for 3 days before trip
- 200 mg per week during trip
- one 200-mg dose in week after return [5]
Tabs: 200 mg (Arakoda), 150 mg (Krintafel)
* 300 mg single-dose (Krintafel) therapy for Plasmodium vivax malaria [4,5]
Interactions
drug adverse effects of antimalarials
General
antimalarial
Database Correlations
PUBCHEM correlations
References
- RxNorm
- PubChem: 115358
- PubChem: 163761
- Lacerda MVG, Llanos-Cuentas A, Krudsood S et al
Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax
Malaria.
N Engl J Med 2019; 380:215-228. Jan 17.
PMID: 30650322
https://www.nejm.org/doi/full/10.1056/NEJMoa1710775?query=TOC
- Llanos-Cuentas A, Lacerda MVG, Hien TT et al
Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium
vivax Malaria.
N Engl J Med 2019; 380:229-241, Jan 17.
PMID: 30650326
https://www.nejm.org/doi/full/10.1056/NEJMoa1802537
- Haston JC, Hwang J, Tan KR.
Guidance for Using Tafenoquine for Prevention and Antirelapse Therapy
for Malaria - United States, 2019.
MMWR Morb Mortal Wkly Rep 2019;68:1062-1068
PMID: 31751320 Free Article
https://www.cdc.gov/mmwr/volumes/68/wr/mm6846a4.htm