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transcription initiation factor TFIID subunit 6; p70TFIID; RNA polymerase II TBP-associated factor subunit E; transcription initiation factor TFIID 70 kD subunit; TAF(II)70; TAFII-70; TAFII70; transcription initiation factor TFIID 80 kD subunit; TAF(II)80; TAFII-80; TAFII80 (TAF6, TAF2E, TAFII70)
Function:
- component of TFIID complex, PCAF complex & TFTC complex
- the TAF6-TAF9 heterodimer forms an octamer complex with the TAF4B-TAF12 heterodimer
- interacts with the GTFs, GTF2E1 & GTF2F1
Structure: belongs to the TAF6 family
Compartment: nucleus
Alternative splicing: named isoforms=2
General
phosphoprotein
transcription factor IID subunit
Properties
SIZE: entity length = 677 aa
MW = 73 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S626}
Ser phosphorylation site {S634}
Ser phosphorylation site {S636}
Ser phosphorylation site {S653}
Thr phosphorylation site {T660}
Ser phosphorylation site {S670}
Ser phosphorylation site {S672}
Database Correlations
OMIM 602955
UniProt P49848
Pfam PF07571
Entrez Gene 6878
Kegg hsa:6878
References
- Chiang CM, Roeder RG.
Cloning of an intrinsic human TFIID subunit that interacts
with multiple transcriptional activators.
Science. 1995 Jan 27;267(5197):531-6.
PMID: 7824954
- UniProt :accession P49848
- NIEHS-SNPs
http://egp.gs.washington.edu/data/taf6/
Component-of
PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex