transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D)

Function: - component of TFIID complex, PCAF complex & TFTC complex - TAF5 interacts strongly with the histone H4-related TAF6 & the histone H3-related TAF9 - forms a stable complex with TAF6 - weaker interaction with TBP, TAF1, TAF11 & TAF12 Structure: - distinct domains of TAF5 are required for functional interaction with transcription factor TFIIFB (RAP30) & incorporation into the TFIID complex - belongs to the WD repeat TAF5 family - contains 1 LisH domain - contains 6 WD repeats Compartment: nucleus Alternative splicing: named isoforms=2

General

transcription factor IID subunit WD repeat protein family

Properties

SIZE: entity length = 800 aa MW = 87 kD COMPARTMENT: cell nucleus MOTIF: glycine-rich region {46-49} LisH {92-124} lysine-rich region {399-407} MOTIF: lysine residue (SEVERAL) WD repeat {468-507} WD repeat {541-580} WD repeat {583-624} WD repeat {625-666} WD repeat {667-706} WD repeat {709-748}

Database Correlations

OMIM 601787 UniProt Q15542 PFAM correlations Entrez Gene 6877 Kegg hsa:6877

References

UniProt :accession Q15542