Search
transcription initiation factor TFIID subunit 4; p136TFIID; RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; transcription initiation factor TFIID 130 kD subunit; TAF(II)130; TAFII-130; TAFII130; transcription initiation factor TFIID 135 kD subunit; TAF(II)135; TAFII-135; TAFII135 (TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135)
Function:
- component of TFIID complex & TFTC-HAT complex
Structure: contains 1 TAFH (NHR1) domain
Compartment: nucleus
General
transcription factor IID subunit
Properties
SIZE: entity length = 1085 aa
MW = 110 kD
COMPARTMENT: cell nucleus
MOTIF: histidine-rich region {39-42}
MOTIF: histidine residue (SEVERAL)
alanine-rich region {52-57}
MOTIF: alanine residue (SEVERAL)
glycine-rich region {98-101}
alanine-rich region {142-148}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 270-277
MOTIF: proline residue (SEVERAL)
alanine-rich region {333-339}
MOTIF: alanine residue (SEVERAL)
TAFH {590-687}
MOTIF: proline-rich region
SITE: 682-685
MOTIF: proline residue (SEVERAL)
alanine-rich region {810-815}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 601796
UniProt O00268
PFAM correlations
Entrez Gene 6874
Kegg hsa:6874
References
- Chiang CM, Roeder RG.
Cloning of an intrinsic human TFIID subunit that interacts
with multiple transcriptional activators.
Science. 1995 Jan 27;267(5197):531-6.
PMID: 7824954
- UniProt :accession O00268
- NIEHS-SNPs
http://egp.gs.washington.edu/data/taf4/
Component-of
TFTC-HAT complex (TATA-binding protein-free TAF complex, TBP-free TAFII complex, TFTC)