transforming acidic coiled-coil-containing protein 1 (taxin 1, gastric cancer antigen Ga55, TACC1, KIAA1103)

Function: 1) cell division prior to formation of differentiated tissues. 2) interacts with KIAA0097/CH-TOG & with oncogenic transcription factor YEATS4 3) interacts with Aurora kinase A & Aurora kinase B (STK6 & AURKB) 4) interacts with LSM7, TDRD7 & SNRPG 5) isoform 1 is heavily phosphorylated Structure: 1) belongs to the TACC family 2) contains 2 SPAZ domains (Ser/Pro-rich AZU-1 domains) Compartment: - cytoplasm, nucleus during interphase - weakly concentrated at centrosomes during mitosis Alternative splicing: - named isoforms=8 - additional isoforms seem to exist Expression: - isoform 1, 3 & 5 are ubiquitous - isoform 2 is strongly expressed in the brain, weakly expressed in lung & colon - isoform 4 is not detected in normal tissues - expressed at high level during early embryogenesis Pathology: 1) isoform 2 overexpressed in gastric cancer 2) isoform 4 is not detected in normal tissues, but strong expression found in gastric cancers 3) down-regulated in a subset of cases of breast cancer

Properties

SIZE: MW = 88 kD entity length = 805 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: binding site SITE: 1-55 FOR-BINDING-OF: U6 snRNA-associated Sm-like protein LSm7 small nuclear ribonucleoprotein G binding site SITE: 152-259 FOR-BINDING-OF: tudor domain-containing protein 7 binding site SITE: 206-427 FOR-BINDING-OF: YEATS domain-containing protein 4 MOTIF: SPAZ 1 {215-297} nuclear translocation signal {226-241} SPAZ 2 {359-507} MOTIF: nuclear translocation signal {455-471} Tyr phosphorylation site {Y533} coiled coil {610-805} MOTIF: CH-TOG NAME: CH-TOG SITE: 701-805 FOR-BINDING-OF: CH-TOG

Database Correlations

OMIM 605301 UniProt O75410 Pfam PF05010

References

UniProt :accession O75410