TGF-beta-activated kinase 1 & MAP3K7-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1 (TAB1, MAP3K7IP1)

Function: 1) signaling intermediate between TGFB receptors & MAP3K7 (putative) 2) interacts with MAP3K7 & BIRC7 3) interacts with TRAF6 & MAP3K7 during IL-1 signaling 4) may play a role in mammalian embryogenesis Structure: contains 1 PP2C-like domain Expression: ubiquitous

General

mitogen-activated protein kinase kinase kinase 7-interacting protein (MAP3K7IP, MAP3K7 interacting protein) phosphoprotein

Properties

SIZE: entity length = 504 aa MW = 55 kD MOTIF: Ser phosphorylation site {S7} PP2C-like {64-368} Ser phosphorylation site {S378} serine-rich region {452-457} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 602615 UniProt Q15750 Pfam PF00481 Entrez Gene 10454 Kegg hsa:10454

References

UniProt :accession Q15750