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T helper 1 (Th1)

Function: Production of cytokines: 1) IFN-gamma, IFN-alpha [4] 2) TNF-beta in addition to GM-CSF, IL-2, IL-3, IL-10, IL-13 produced by both Th1 & Th2 cells. Additional functions: - executes cell-mediated immune responses a) delayed hypersensitivity b) macrophage activation c) immune response to viruses & bacteria

Related

granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF) interferon [IFN]-gamma; interferon type 2; immune interferon (IFNG) interleukin-10; IL-10; cytokine synthesis inhibitory factor; CSIF (IL10) interleukin-13 (IL13, IL-13, NC30) interleukin-2; IL-2; T-cell growth factor; TCGF (IL2) interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3) lymphotoxin-alpha; LT-alpha; TNF-beta; tumor necrosis factor ligand superfamily member 1 (LTA, TNFB, TNFSF1) macrophage type 4 hypersensitivity; T-cell-mediated (delayed) hypersensitivity

General

helper T cell (T4 lymphocyte, CD4+)

References

  1. Scott P IL-12: initiation cytokine for cell-mediated immunity Science 260:496 1993 PMID: 8097337
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Journal Watch 22(4):31, 2002
  4. Finn, PW UC San Diego