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T-cell lymphoid neoplasm (T-cell leukemia, T-cell lymphoma)
Genetics:
- overexpression of MTCP1 in T-cell leukemia bearing a t(X;14) translocation
- chromosomal aberrations involving T-cell receptor alpha/delta loci activating TCL1A are found in chronic T-cell leukemias
- translocation t(14;14)(q11;q32)
- translocation t(7;14)(q35;q32)
- inversion inv(14)(q11;q32)
- TCL6 activated in T-cell leukemias with rearrangements at chromosome 14q32.1
- TNG2 activated in T-cell leukemias with rearrangements at chromosome 14q32.1
- translocations associated with TCTA
- chromosomal translocation t(X;14)(q28;q11) involving BRCC3 with TCRA
- overexpression of BCL11B, RBM5
- other implicated genes PCM1, TREML2
Laboratory:
- see ARUP consult [1]
Interactions
disease interactions
Specific
hepatosplenic T-cell lymphoma (HSTCL)
peripheral T-cell lymphoid neoplasm
precursor T-cell lymphoid neoplasm
General
non-Hodgkin's lymphoma
References
- ARUP Consult: T-Cell/NK-Cell Lymphomas
The Physician's Guide to Laboratory Test Selection & Interpretation
https://www.arupconsult.com/content/lymphomas-t-cellnk-cell
- Horwitz, SM, Ansell SM, Ai WZ, et al.
NCCN Guidelines Insights: T-Cell Lymphomas, Version 2.2018.
J Natl Compr Canc Netw. 2018 Feb;16(2):123-135.
PMID: 29439173
http://www.jnccn.org/content/16/2/123.long