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chromosomal translocation t(8;22)(p11;q13) (acute myeloid leukemia)
- chromosomal translocation t(8;22)(p11;q13) involving MYST3 with EP300 may be a cause of acute myeloid leukemia
Properties
GENERAL: chromosomal translocation
FORM: t8p11:22q12
LOCUS: human chromosome-8 P11
human chromosome-22 Q13
PATHOLOGY: acute myeloid leukemia (AML)
ABERRANT-GENE: histone acetyltransferase MYST3
COMPARTMENT: cell nucleus
MOTIF: activation of RUNX1-1 {1-144}
nuclear localization {52-166}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 206-265
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 259-313
EFFECTOR-BOUND: Zn+2
RUNX1-1 interaction {312-664}
MOTIF: serine-rich region {371-379}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S473}
active site
SITE: 488-778
MOTIF: Zn finger C2HC-type
SITE: 538-560
EFFECTOR-BOUND: Zn+2
binding site
SITE: 635-668
FOR-BINDING-OF: ACETYLCOENZYME-A
cysteine residue {C646}
glutamate-rich region {788-801}
MOTIF: glutamate residue (SEVERAL)
breakpoint {813-814}
Thr phosphorylation site {T909}
Ser phosphorylation site {S941}
glutamate-rich region {989-995}
MOTIF: glutamate residue (SEVERAL)
arginine-rich region {1019-1026}
MOTIF: arginine residue (SEVERAL)
glutamate-rich region {1069-1078}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1113}
breakpoint {1117-1118}
lysine-rich region {1147-1150}
MOTIF: lysine residue (SEVERAL)
glutamate-rich region {1221-1242}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {1267-1302}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {1411-1414}
MOTIF: glutamate residue (SEVERAL)
RUNX1-2 interaction {1517-1642}
MOTIF: breakpoint {1546-1547}
serine-rich region {1593-1597}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 1643-1704
MOTIF: proline residue (SEVERAL)
activation of RUNX1-2 {1913-1948}
histone acetyltransferase p300
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {11-17}
breakpoint {31-32}
Zinc finger
NAME: Zinc finger
SITE: 331-417
EFFECTOR-BOUND: Zn+2
KIX {566-645}
serine-rich region {797-800}
MOTIF: serine residue (SEVERAL)
bromodomain {1067-1139}
glutamate-rich region {1519-1526}
MOTIF: glutamate residue (SEVERAL)
Binding region for E1A adenovirus {1572-1818}
MOTIF: Zn finger ZZ-type
NAME: Zn finger ZZ-type
SITE: 1664-1707
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 1728-1809
EFFECTOR-BOUND: Zn+2
HTLV-1 Tax interaction {2003-2212}
NCOA2 interaction {2041-2240}
MOTIF: glutamine-rich region {2066-2069}
MOTIF: glutamine residue (SEVERAL)
arginine residue {2088}
arginine residue {2142}
glutamine-rich region {2190-2195}
MOTIF: glutamine residue (SEVERAL)
References
UniProt :accession Q92794