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podoplanin; Aggrus; glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A (PDPN, GP36, PSEC0003, PSEC0025, D2-40)

Function: - mucin like protein - may play role in tumor progression - cell migration &/or actin cytoskeleton organization - lung cell proliferation & alveolus formation at birth - induces platelet aggregation - when expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility & decreased cell adhesion - does not have any effect on folic acid or amino acid transport - does not function as a water channel or as a regulator of aquaporin-type water channels Structure: - belongs to the podoplanin family - O-glycosylation (sialic acid) necessary for platelet aggregation - the N-terminus is blocked (putative) Compartment: - localized to actin-rich microvilli & plasma membrane projections (filopodia, lamellipodia, ruffles) - apical plasma membrane of endothelium Alternative splicing: named isoforms=2 Expression: - expressed in placenta, lung, skeletal muscle, brain > brain, kidney, liver - expressed in: - apical plasma membrane of endothelium - alveolar epithelium Pathology: - up-regulated in colorectal tumors - expressed in 25% of early oral squamous cell carcinomas

Related

D2-40 (podoplanin) Ag in tissue

General

membrane protein sialoglycoprotein

Properties

SIZE: MW = 17 kD entity length = 162 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-22} Thr glycosylation site {T25-T85} (10) Ser glycosylation site {S86-S88} (2) Thr glycosylation site {T89} Ser glycosylation site {S96} Ser glycosylation site {S98} Thr glycosylation site {T100} Ser glycosylation site {S102} Thr glycosylation site {T106} Ser glycosylation site {S107} Ser glycosylation site {S109} Thr glycosylation site {T110-T120} (4) transmembrane domain {132-152}

Database Correlations

OMIM 608863 UniProt Q86YL7 Pfam PF05808 Entrez Gene 10630 Kegg hsa:10630

References

  1. UniProt :accession Q86YL7
  2. Pernick N PathologyOutlines. Stains. D2-40 (Podoplanin) http://www.pathologyoutlines.com/topic/stainD240.html