chromosomal translocation t11q32 17q21 (acute promyelocytic leukemia)

- chromosomal translocation t(11;17)(q32;q21) involving ZBTB16 with RARA may be a cause of acute promyelocytic leukemia

Properties

GENERAL: chromosomal translocation RELATED: retinoic acid receptor alpha zinc finger & BTB domain-containing protein 16 FORM: t(11;17)(q32;q21) LOCUS: human chromosome-11 Q23 human chromosome-17 Q25 ABERRANT-GENE: zinc finger & BTB domain-containing protein 16 COMPARTMENT: cell nucleus MOTIF: BTB domain {34-96} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S76} Ser phosphorylation site {S184} Ser phosphorylation site {S197} Ser phosphorylation site {S256} Thr phosphorylation site {T282} breakpoint {394-395} Zn finger C2H2-type SITE: 404-426 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 432-454 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 461-483 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 490-512 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 518-540 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 546-568 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 574-596 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 602-624 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S628} Zn finger C2H2-type SITE: 630-652 EFFECTOR-BOUND: Zn+2 retinoic acid receptor alpha COMPARTMENT: cell nucleus MOTIF: Modulating {1-87} MOTIF: breakpoint {60-61} Ser phosphorylation site {S77} DNA-binding motif SITE: 88-153 MOTIF: Zn finger C4-type SITE: 88-108 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 124-148 EFFECTOR-BOUND: Zn+2 Hinge {154-199} binding site SITE: 200-419 FOR-BINDING-OF: ligand Ser phosphorylation site {S449} Ser phosphorylation site {S456} Ser phosphorylation site {S461}

References

UniProt :accession Q05516