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synaptotagmin-11; synaptotagmin XI; SytXI (SYT11 KIAA0080)
Function:
- may be involved in Ca+2-dependent exocytosis of secretory vesicles through Ca+2 & phospholipid binding to the C2 domain or may serve as Ca+2 sensors in the process of vesicular trafficking & exocytosis (putative)
- ubiquitinated & targeted to the proteasome complex for degradation
- interacts with PARK2
Cofactor: binds 3 Ca+2 per subunit via the C2 domains (putative)
Structure:
- homodimer
- can also form heterodimers (putative)
- belongs to the synaptotagmin family
- contains 2 C2 domains
Compartment:
- membrane, cell junction, synapse (putative)
- cytoplasmic vesicle, secretory vesicle
- synaptic vesicle membrane
- in substantia nigra, observed in neuronal cell bodies & neurites
Pathology:
- found in the core of the Lewy bodies in the brain of sporadic parkinson disease patients
General
synaptotagmin
Properties
SIZE: entity length = 431 aa
MW = 48 kD
COMPARTMENT: cytoplasm
MOTIF: Vesicular {1-15}
transmembrane domain {16-36}
C2 domain {174-262}
MOTIF: binding site
FOR-BINDING-OF: phospholipid
Ca+2-binding site
SITE: 188-188
Ca+2-binding site
SITE: 195-195
Ca+2-binding site
SITE: 249-249
Ca+2-binding site
SITE: 250-250
Ca+2-binding site
SITE: 253-253
Ca+2-binding site
SITE: 256-256
C2 domain {304-397}
MOTIF: binding site
FOR-BINDING-OF: phospholipid
Ca+2-binding site
Database Correlations
OMIM 608741
UniProt Q9BT88
Pfam PF00168
Entrez Gene 23208
Kegg hsa:23208
References
- UniProt :accession Q9BT88
- Entrez Gene :accession 23208