Search
synovial sarcoma
Mesenchymal neoplasm, unknown histogenesis does not derive from synovium or show any synovial differentiation.
Epidemiology:
- 4th most common type of soft tissue sarcoma
- commonly metastasizes to lung & pleura.
Microscopic pathology:
1) biphasic pattern - with epithelial differentiation
2) monophasic pattern - epithelial differentiation not apparent, mostly sheets of spindle cells
3) poorly differentiated - oval to round cells, scant extracellular matrix, high mitotic activity
Immunopathology:
1) biphasic: epithelial areas positive for:
a) K7, K8, K14, K18, K19 (extensive)
b) K17 (77%)
c) K13 (25%)
d) K16 (23%)
e) K6 (24%)
f) K20 (focal 27%)
g) EMA
h) calretinin (71% spindle or epithelial component)
i) HBME-1 (28/28 epithelial)
2) monophasic: simple epithelial keratin positivity, usually focal
a) K7 (79%)
b) K19 (60%)
c) K8 (45%)
d) K18 (46%)
e) EMA (85%, patchy, clusters)
f) calretinin (52%)
g) HBME-1 (8/20 focal)
Genetics:
- t(X;18) (p11;q11) chromosomal translocation.
Interactions
disease interactions
Related
keratin
Specific
synovial sarcoma/t[X;18][p11;q11]
General
soft tissue sarcoma (STS)
References
- Miettinen et al. Virchows Arch 437:275-83, 2000
- Miettinen et al. Am J Surgical Pathology 25:610-17, 2001
- Cancer Facts: Synovial Sarcoma
http://cis.nci.nih.gov/fact/6_1.htm
Images
images related to synovial sarcoma