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synaptojanin-2; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2 (SYNJ2, KIAA0348)
Function:
- inositol 5-phosphatase
- may be involved in distinct membrane trafficking & signal transduction pathways
- may mediate the inhibitory effect of Rac1 on endocytosis
- binds to GRB2
- isoform 2A binds to SYNJ2BP/OMP25
- isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 & GRB2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Structure:
- belongs to the synaptojanin family
- in the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family
- contains 1 RRM domain (RNA recognition motif)
- contains 1 SAC domain
Compartment:
- membrane (putative)
- predominantly associated with the particulate fractions (putative)
Alternative splicing:
- named isoforms=3; 2B2, 2B1, 2A
- additional isoforms seem to exist
General
phosphomonoesterase
phosphoprotein
RNA-binding protein
Properties
SIZE: entity length = 1496 aa
MW = 166 kD
MOTIF: Sac phosphatase domain {120-444}
MOTIF: Tyr phosphorylation site {Y130}
RNP motif
NAME: RNP motif
SITE: 889-968
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
proline-rich region
SITE: 1099-1114
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1191}
proline-rich region
SITE: 1209-1334
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 609410
UniProt O15056
PFAM correlations
Entrez Gene 8871
Kegg hsa:8871
ENZYME 3.1.3.36
References
UniProt :accession O15056