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syndecan-1; SYND1; CD138 (SDC1, SDC)
Function:
- cell surface proteoglycan that bears both heparan sulfate & chondroitin sulfate & that links the cytoskeleton to the interstitial matrix
- plasma membrane embedded proteoglycan core protein
- interacts with CDCP1
Structure: belongs to the syndecan proteoglycan family
Compartment: plasma membrane
Related
CD138 Ag in tissue
CD138 cells in blood
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
proteoglycan core protein
Properties
SIZE: entity length = 310 aa
MW = 32 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-22}
Ser glycosylation site {S37}
N-glycosylation site {N43}
Ser glycosylation site {S45}
Ser glycosylation site {S47}
Ser glycosylation site {S206}
Ser glycosylation site {S216}
peptide motif {250-251}
transmembrane domain {255-275}
Tyr phosphorylation site {Y309}
Database Correlations
OMIM 186355
UniProt P18827
Pfam PF01034
Entrez Gene 6382
Kegg hsa:6382
References
- UniProt :accession P18827
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/SDC1ID42223ch2p24.html