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nafarelin (Synarel)

Tradename: Synarel. Indications: - endometriosis - precocious puberty [3] Dosage: - 200-400 ug (1 spray each nostril) intranasally BID for 6 months Solution: (nasal) 2 mg/mL (10 mL) Adverse effects: 1) common (> 10%) - hot flashes, decreased libido, vaginal dryness, headache, emotional lability, myalgia, decreased breast size, nasal irritation 2) less common (1-10%) - edema, insomnia, seborrhea 3) uncommon (< 1%) - increased libido, weight loss Mechanism of action: -> GnRH analog

Interactions

drug adverse effects of GnRH agonists

General

gonadotropin-releasing hormone agonist (GnRH analog)

Properties

MISC-INFO: elimination route LIVER pregnancy-category X safety in lactation -

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. Prescriber's Letter 11(8): 2004
  3. Deprecated Reference