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synaptic plasticity; neuronal plasticity
The ability of a synapse to undergo remodeling in response to activity, including ionic currents & depolarization. Synaptic plasticity (via long-term potentiation {in part}) is thought to form the basis of learning & memory.
Similarities with synaptogensis.
In humans, MRI-detectable changes in grey matter volume can accompany acquisition of a skill [2]. Cessation of practice of the skill can result in reduction in grey matter acquired with skill acquisition.
Proteins implicated in synaptic plasticity:
- also see long-term potentiation
- ARC
Related
long term depression (LTD)
long term potentiation (LTP)
paired-pulse facilitation
synaptogenesis
General
physiology
plasticity
References
- Ghosh A.
Neurobiology. Learning more about NMDA receptor regulation.
Science. 2002 Jan 18;295(5554):449-51. No abstract available.
PMID: 11799227
- Journal Watch 24(5):42, 2004
Draganski B et al, Nature 427:311, 2004
PMID: 14737157