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Swedish Trial in Old Patients (STOP)
Patients:
1) 6614 patients, age 70-84 years
2) systolic BP > 180 mm Hg &/or diastolic BP > 105 mm Hg
3) random assignment of 3 groups
a) beta-blocker or diuretic
b) ACE inhibitor (enalapril or lisinopril)
c) Ca+2 channel blocker (felodipine or isradipine)
Results:
1) blood pressure declines in the treatment groups from a mean of 194/98 to 159/81 mm Hg
2) after 4.5 years, the combined endpoint of stroke or myocardial infarction were the same in all 3 groups
General
hypertension clinical trials