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SV40 T antigen
Pathology:
- the SV40 large T antigen is a multifunctional viral protein derived from Papovaviridae essential for the transforming capacity of SV40 in nonpermissive cells.
- large T antigen appears to function by sequestering Rb & p53 tumor suppressor proteins
- large T antigen is by itself a DNA-binding protein & can regulate both transcription & replication
- phosphorylation by casein kinase 2 enhances cytoplasmic to nuclear translocation of SV40 large T
Interactions
molecular events
General
polyomavirus T antigen
Properties
MOTIF: Ser phosphorylation site {S111}
FOR-PHOSPHORYLATION-BY: casein kinase 2
Ser phosphorylation site {S112}
FOR-PHOSPHORYLATION-BY: casein kinase 2
binding site
FOR-BINDING-OF: retinoblastoma-associated protein
binding site
FOR-BINDING-OF: cellular tumor antigen p53
References
- Allende JE, Allende CC.
Protein kinases. 4. Protein kinase CK2: an enzyme with
multiple substrates and a puzzling regulation.
FASEB J. 1995 Mar;9(5):313-23. Review.
PMID: 7896000
Component-of
molecular complex