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polycomb protein SUZ12 (suppressor of zeste 12 protein homolog, joined to JAZF1 protein, chromatin precipitated E2F target 9 protein, ChET 9 protein, SUZ12, CHET9, JJAZ1, KIAA0160)
Function:
1) polycomb group (PcG) protein.
2) component of the PRC2 complex, which methylates Lys-9 & Lys-27 residues of histone H3
3) induced by E2F1 transcription factor
Structure:
1) belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
2) contains 1 C2H2-type zinc finger
Compartment: nucleus
Pathology:
- chromosomal translocation t(7;17)(p15;q21) with JAZF1 generates JAZF1-SUZ12 oncogene (N-terminus of JAZF1 & C-terminus of SUZ12) found in endometrial stromal tumors
General
C2H2 type zinc finger protein
phosphoprotein
Properties
SIZE: MW = 83 kD
entity length = 739 aa
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {7-50}
serine-rich region {51-59}
MOTIF: serine residue (SEVERAL)
alanine-rich region {60-67}
MOTIF: alanine residue (SEVERAL)
Zn finger C2H2-type
SITE: 448-471
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S546}
VEFS-box. {563-639}
Database Correlations
OMIM 606245
UniProt Q15022
References
- UniProt :accession Q15022
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/JJAZ1ID41039ch17q11.html
Component-of
PRC2/EED-EZH1 complex